Nutritional Genomic: (perspective) – Article Example
Nutritional Genomic: (perspective) Nutritional genomics which is also known as nitrigenomics is a widely recognized term that has renewed benefit interest in nutrition research. Nutritional genemics definitions range from the high-throughput genomic applications to nutrition research and to the enhancement of genetic of plants for higher quality of nutrition. Discovery and research in nutritional genomics make clear the reciprocal interactions between metabolic intermediated, nutrients and the mammalian genome. It enhances the understanding of interrelationships among genome function, genetic diversity and dietary components, which, enables exact manipulation of stability all the way in the life cycle for best human health and prevention of diseases.
In this perspective, primary sequence of human genome and the variation in genetics that are in human species are due to molecular adaptation to pressures of evolution. Gene mutation rate is highly affected by individual dietary components. Furthermore, environmental factors such as nutrients influence feat viability and alter the penetarnce of genetic lesions. Nutritional requirements were identified to be complex traits that are subject to change by both nutrient-nutrient interaction and genetic background. Genetic background alters both minimal nutrient requirement and the upper intake tolerable levels. Moreover, a common polymorphism in the methylenetetrahydrofolate reductase (MTHFR) gene (A222V) give substitution of protein with amino that changes its affinity and stability for its riboflavin factor. The polymorphism in MTHFR decreases risk of colon cancer. However, it has an enzyme that is a risk factor for cardiovascular and neural tube defects.
It is evident that the impact of genetic variation on public health nutrition policy is not very clear. Therefore, more research is needed. The factors affecting genetic variations keep changing as the technology advances. Another issue is on the nutrigenomic aspects of diabetes, various cancers and cardiovascular disease. More needs to be researched so as to establish the link between nutrigenomic and the disease. In conclusion, reviews show that new science of nutritional genomics comes with lots of opportunities and challenges to the field of nutrition than the solutions it provides.
Stover, P. J. (2003). Nutritional genomics. Division of Nutritional Sciences, 14, 53.